Systematic review of microRNAs in human acute kidney injury.

ABSTRACT:

Introduction

Early diagnosis of acute kidney injury (AKI) is limited with current tools. MicroRNAs (miRNAs) are implicated in AKI pathogenesis in preclinical models, but less is known about their role in humans. We conducted a systematic review to identify dysregulated miRNAs in humans with AKI.

Methods

We searched Ovid MEDLINE, Embase, Web of Science, and CENTRAL (August 21, 2023) for studies of human subjects with AKI. We excluded reviews and pre-clinical studies without human data. The primary outcome was dysregulated miRNAs in AKI. Two reviewers screened abstracts, reviewed full texts, performed data extraction and quality assessment (Newcastle Ottawa Scale).

Results

We screened 2,456 reports and included 92 for synthesis without meta-analysis. All studies except

SUBMITTER: Douvris A 

PROVIDER: S-EPMC11533245 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature