Alterations of oral microbiome and metabolic signatures and their interaction in oral lichen planus.

ABSTRACT:

Background

Oral lichen planus (OLP) is a chronic oral mucosal inflammatory disease with a risk of becoming malignant. Emerging evidence suggests that microbial imbalance plays an important role in the development of OLP. However, the association between the oral microbiota and the metabolic features in OLP is still unclear.

Methods

We conducted 16S rRNA sequencing and metabolomics profiling on 95 OLP patients and 105 healthy controls (HC).To study oral microbes and metabolic changes in OLP, we applied differential analysis, Spearman correlation analysis and four machine learning algoeithms.

Results

The alpha and beta diversity both differed between OLP and HC. After adjustment for gender and age, we found an increase in the relative abundance of Pseudomonas,

SUBMITTER: Yan L 

PROVIDER: S-EPMC11533246 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature