Intestinal commensal bacteria promote Bactrocera dorsalis larval development through the vitamin B6 synthesis pathway.

ABSTRACT:

Background

The gut microbiota can facilitate host growth under nutrient-constrained conditions. However, whether this effect is limited to certain bacterial species remains largely unclear, and the relevant underlying mechanisms remain to be thoroughly investigated.

Results

We found that the microbiota was required for Bactrocera dorsalis larval growth under poor dietary conditions. Monoassociation experiments revealed that Enterobacteriaceae and some Lactobacilli promoted larval growth. Among the 27 bacterial strains tested, 14 significantly promoted larval development, and the Enterobacteriaceae cloacae isolate exhibited the most obvious promoting effect. A bacterial genome-wide association study (GWAS) revealed that the vitamin B6 synthesis pathway was critical for the pr

SUBMITTER: Gu J 

PROVIDER: S-EPMC11533292 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature