Liquid crystalline collagen assemblies as substrates for directed alignment of human Schwann cells.

ABSTRACT: Collagen is a key component of the extracellular matrix (ECM) and well-oriented domains of collagen are important for mimicking the local cell environment in vitro. While there has been significant attention directed towards the alignment of collagen, formation of large-scale oriented domains remains a key challenge. Type I collagen self-assembles to form liquid crystalline (LC) mesophases in acidic conditions at concentrations above 100 mg mL^-1. The LC mesophase provides an efficient platform for large-scale alignment and patterning of collagen coated substrates. However, there still exist challenges related to solubilizing and processing of collagen at such high concentrations in order to replicate the native ECM. In this contribution, we report on centimeter-scale alig

SUBMITTER: Ghaiedi H 

PROVIDER: S-EPMC11533399 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature