GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states.

ABSTRACT: G-protein coupled receptors (GPCRs), the largest family of membrane proteins in human body, involve a great variety of biological processes and thus have become highly valuable drug targets. By binding with ligands (e.g., drugs), GPCRs switch between active and inactive conformational states, thereby performing functions such as signal transmission. The changes in binding pockets under different states are important for a better understanding of drug-target interactions. Therefore it is critical, as well as a practical need, to obtain binding sites in human GPCR structures. We report a database (called GPCR-BSD) that collects 127,990 predicted binding sites of 803 GPCRs under active and inactive states (thus 1,606 structures in total). The binding sites were identified from the predicted G

SUBMITTER: Liu F 

PROVIDER: S-EPMC11533411 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature