Immunopathological markers and cell types linked to COVID-19 symptom manifestation.

ABSTRACT:

Background

Numerous studies have investigated the molecular properties that contribute to the symptoms of COVID-19, such as the virus's genetic makeup, its replication mechanisms, and how it interacts with host cells. However, identifying the immunopathological properties, such as the immune system's response, cytokine levels, and the presence of specific biomarkers, that are associated with the severity of the infection remains crucial for developing effective treatments and preventions.

Methods

We analyzed blood protein factor profiles from 420 individuals to identify features differentiating between test-negative healthy, asymptomatic, and symptomatic individuals using statistical comparison and the least absolute shrinkage and selection operator (i.e., LASSO) algorithm.

SUBMITTER: Song HW 

PROVIDER: S-EPMC11533414 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature