Understanding energy fluctuation during the transition state: The role of AbrB in Bacillus licheniformis.

ABSTRACT:

Background

Limited research has been conducted on energy fluctuation during the transition state, despite the critical role of energy supply in microbial physiological metabolism.

Results

This study aimed to investigate the regulatory function of transition state transcription factor AbrB on energy metabolism in Bacillus licheniformis WX-02. Firstly, the deletion of abrB was found to prolong the cell generation time, significantly reducing the intercellular ATP concentration and NADH/NAD⁺ ratio at the early stage. Subsequently, various target genes and transcription factors regulated by AbrB were identified through in vitro verification assays. Specifically, AbrB was shown to modulate energy metabolism by directly regulating the expression of genes pyk and pgk in

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11533420 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature