Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model.

ABSTRACT:

Purpose

Radiation therapy (RT) exerts its anti-tumour efficacy by inducing direct damage to cancer cells but also through modification of the tumour microenvironment (TME) by inducing immunogenic antitumor response. Conversely, RT also promotes an immunosuppressive TME notably through the recruitment of regulatory T cells (Tregs). Glycoprotein A repetitions predominant (GARP), a transmembrane protein highly expressed by activated Tregs, plays a key role in the activation of TGF-β and thus promotes the immunosuppressive action of Tregs. The development of a theranostic approach targeting GARP combining imaging and targeted radionuclide therapy (TRT) was carried out.

Methods

A preclinical model of 4T1 triple negative breast tumour-bearing BALB/c mice was used to show that GARP

SUBMITTER: Bellaye PS 

PROVIDER: S-EPMC11533616 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature