A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models.

ABSTRACT:

Objective

The objective was to critically analyze the published literature accounting for sex differences and skeletal age (open vs. closed physis) in preclinical animal models of OA, including the disaggregation of data by sex and skeletal maturity when data is generated from combined sex and/or multi-aged cohorts without proper confounding.

Method

A scoping literature review of PubMed, Web of Science, EMBASE, and SCOPUS was performed for studies evaluating the effect of sex and age in experimental studies and clinical trials utilizing preclinical large animal models of OA.

Results

A total of 9727 papers were identified in large animal (dog, pig, sheep, goat, horse) models for preclinical OA research, of which 238 ex vivo and/or in vivo studies disclosed model type,

SUBMITTER: Stewart HL 

PROVIDER: S-EPMC11534084 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature