Hsa-miR-582-3p in umbilical cord blood is negatively associated with maternal exposure to childhood maltreatment.

ABSTRACT: Aim: Childhood maltreatment (CM) may affect not only directly exposed individuals but also their offspring. However, the underlying biological mechanisms remain unclear. microRNAs (miRNAs) may play a regulatory role in this process. This study investigates the relationship between maternal exposure to CM and miRNA expression in maternal and perinatal tissues.Methods: We enrolled 43 pregnant women and assessed their CM exposure. We collected maternal blood, cord blood and placental tissue samples during childbirth and performed miRNA profiling using next generation sequencing.Results: Maternal CM was inversely associated with hsa-miR-582-3p levels in cord blood. Pathway analysis revealed that this miRNA regulates genes involved in intrauterine development.Conclusion:

SUBMITTER: Micali D 

PROVIDER: S-EPMC11534114 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature