Longitudinal analysis of serum urate in prediabetic phase.

ABSTRACT:

Objectives

Despite the well-established association between prediabetes and hyperuricaemia, knowledge about serum urate (SU) trends during the prediabetic phase is limited. Therefore, we aimed to assess the longitudinal changes of SU in individuals with prediabetes.

Methods

Individuals with prediabetes, defined by initial haemoglobin A1c (HbA1c) levels between 5.7% and 6.4%, were identified using electronic health records from an academic health system (2007-2022). We required at least one SU test before and after the prediabetes diagnosis. The primary outcome was the longitudinal SU trends during the follow-up period, estimated with a multivariable mixed-effects model. Patients were censored at diabetes onset. Marginal effects of covariates on SU changes were estimated. Sub

SUBMITTER: Marrugo J 

PROVIDER: S-EPMC11534116 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature