Antibody predictors of mortality and lung function trends in myositis spectrum interstitial lung disease.

ABSTRACT:

Objectives

The impact of autoantibody profiles on the prognosis for idiopathic inflammatory myositis-associated interstitial lung disease (IIM-ILD) and myositis spectrum ILD with myositis-specific antibodies (MSAs) remains unclear. This retrospective cohort study examined whether serological profiles were associated with mortality or longitudinal lung function change.

Methods

The baseline clinical/demographic characteristics and follow-up lung function data of consecutive adult patients with IIM-ILD or interstitial pneumonia with autoimmune features (IPAF) positive for MSAs (IPAF-MSA) were extracted from three hospitals. Univariate and multivariate Cox proportional hazards analyses were used to compare mortality between groups of patients with different autoantibodies. Regre

SUBMITTER: Hannah JR 

PROVIDER: S-EPMC11534121 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature