Placental lesions in systemic lupus erythematosus pregnancies associated with small for gestational age infants.

ABSTRACT:

Objectives

Up to a quarter of pregnant individuals with SLE have small for gestational age (SGA) infants. We aimed to characterize placental pathology associated with SGA infants in SLE.

Methods

We retrospectively analysed SLE deliveries with placental analysis at UCSD from November 2018 to October 2023, comparing SLE pregnancies resulting in SGA to those that did not, and additionally, to matched pregnancies with SGA but without SLE.

Results

Placental analysis was available only for 28/70 (40%) SLE deliveries, which had high rates of adverse outcomes (75%). All exhibited at least one histopathologic abnormality. Key findings distinguishing 12 SLE placentas resulting in SGA infants (vs.16 without) included small placental disc for gestational age (100% vs 56%, P = 0.0

SUBMITTER: Dhital R 

PROVIDER: S-EPMC11534143 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature