A comprehensive framework for trans-ancestry pathway analysis using GWAS summary data from diverse populations.

ABSTRACT: As more multi-ancestry GWAS summary data become available, we have developed a comprehensive trans-ancestry pathway analysis framework that effectively utilizes this diverse genetic information. Within this framework, we evaluated various strategies for integrating genetic data at different levels-SNP, gene, and pathway-from multiple ancestry groups. Through extensive simulation studies, we have identified robust strategies that demonstrate superior performance across diverse scenarios. Applying these methods, we analyzed 6,970 pathways for their association with schizophrenia, incorporating data from African, East Asian, and European populations. Our analysis identified over 200 pathways significantly associated with schizophrenia, even after excluding genes near genome-wide significant l

SUBMITTER: Fu S 

PROVIDER: S-EPMC11534268 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature