Maternal exposure to nitrosamines in drinking water during pregnancy and birth outcomes in a Chinese cohort.

ABSTRACT: Maternal exposure to regulated disinfection by-products (DBPs) during pregnancy has been linked with adverse birth outcomes. However, no human studies have focused on drinking water nitrosamines, a group of emerging unregulated nitrogenous DBPs that exhibits genotoxicity and developmental toxicity in experimental studies. This cohort study included 2457 mother-infant pairs from a single drinking water supply system in central China, and maternal trimester-specific and entire pregnancy exposure of drinking water nitrosamines were evaluated. Multivariable linear and Poisson regression models were used to estimate the associations between maternal exposure to nitrosamines in drinking water and birth outcomes [birth weight (BW), low birth weight (LBW), small for gestational age (SGA) and prete

SUBMITTER: Luo Q 

PROVIDER: S-EPMC11534404 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature