Neutrophil pyroptosis regulates corneal wound healing and post-injury neovascularisation.

ABSTRACT:

Rationale

The cornea is a unique structure that maintains its clarity by remaining avascular. Corneal injuries can lead to neovascularisation (CNV) and fibrosis and are the third most common cause of blindness worldwide.

Objective

Corneal injuries induce an immune cell infiltration to initiate reparative processes. However, inflammation caused by sustained immune cell infiltration is known to be detrimental and can delay the healing process. This study was designed to understand the potential role of neutrophil and epithelial cell crosstalk in post-injury CNV.

Methods and results

Western blotting and immunostaining assays demonstrated that neutrophils infiltrated corneas and underwent pyroptosis following acute alkali injury. In vivo studies showed that genetic ablati

SUBMITTER: Chen P 

PROVIDER: S-EPMC11534482 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature