Diagnostic Validation of the Updated Pediatric Sepsis Biomarker Risk II for Acute Kidney Injury Prediction Model in Pediatric Septic Shock.

ABSTRACT:

Objectives

We previously derived the updated Pediatric Sepsis Biomarker Risk for Acute Kidney Injury (PERSEVERE-II AKI) prediction model, which had robust diagnostic test characteristics for severe AKI on day 3 (D3 severe AKI) of septic shock. We now sought to validate this model in an independent cohort of children to the one in which the model was developed.

Design

A secondary analysis of a multicenter, prospective, observational study carried out from January 2019 to December 2022.

Setting

Ten PICUs in the United States.

Patients

Children with septic shock 1 week to 18 years old admitted to the PICU.

Interventions

None.

Measurements and main results

Seventy-nine of 363 patients (22%) had D3 severe AKI, defined as Kidney Disease Improving Global

SUBMITTER: Stanski NL 

PROVIDER: S-EPMC11534533 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature