Biological effects in normal human fibroblasts following chronic and acute irradiation with both low- and high-LET radiation.

ABSTRACT:

Introduction

Radiobiological studies at low dose rates allow us to improve our knowledge of the mechanisms by which radiation exerts its effects on biological systems following chronic exposures. Moreover, these studies can complement available epidemiological data on the biological effects of low doses and dose rates of ionizing radiation. Very few studies have simultaneously compared the biological effects of low- and high-LET radiations at the same dose rate for chronic irradiation.

Methods

We compared, for the first time in the same experiment, the effects of chronic (dose rates as low as ~18 and 5 mGy/h) and acute irradiations on clonogenicity and micronucleus formation in AG1522 normal human skin fibroblasts in the confluent state exposed to doses of low- and high-LET

SUBMITTER: Anello P 

PROVIDER: S-EPMC11534685 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature