Effects of polygenic risk score and sodium and potassium intake on hypertension in Asians: A nationwide prospective cohort study.

ABSTRACT: Genetic factors, lifestyle, and diet have been shown to play important roles in the development of hypertension. Increased salt intake is an important risk factor for hypertension. However, research on the involvement of genetic factors in the relationship between salt intake and hypertension in Asians is lacking. We aimed to investigate the risk of hypertension in relation to sodium and potassium intake and the effects of genetic factors on their interactions. We used Korean Genome and Epidemiology Study data and calculated the polygenic risk score (PRS) for the effect of systolic and diastolic blood pressure (SBP and DBP). We also conducted multivariable logistic modeling to evaluate associations among incident hypertension, PRS_SBP, PRS_DBP, and sodium and potassium

SUBMITTER: Bae E 

PROVIDER: S-EPMC11534693 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature