Characterization of the single cell landscape in normal and osteoarthritic equine joints.

ABSTRACT:

Background

Osteoarthritis (OA) is a major source of pain and disability worldwide. Understanding of disease progression is evolving, but OA is increasingly thought to be a multifactorial disease in which the innate immune system plays a role in regulating and perpetuating low-grade inflammation. The aim of this study was to enhance our understanding of OA immunopathogenesis through characterization of the transcriptomic responses in OA joints, with the goal to facilitate the development of targeted therapies.

Methods

Single-cell RNA sequencing (scRNA-seq) was completed on cells isolated from the synovial fluid of three normal and three OA equine joints. In addition to synovial fluid, scRNA-seq was also performed on synovium from one normal joint and one OA joint.

Results<

SUBMITTER: Ammons DT 

PROVIDER: S-EPMC11534742 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature