Laparoscopic sigmoid colectomy with primary anastomosis for experimental modeling in the nonhuman primate.

ABSTRACT: Laparoscopic colon surgery is performed frequently in the clinical setting for a multitude of reasons including cancer, infection, and autoimmune disease. As a result, extensive research has been conducted in relation to clinical outcomes after surgery, but more recently, in relation to the impact of surgery and other patient factors on physiologic homeostasis including the host microbiome. Despite this, experimental surgical models for laparoscopic colon surgery are scarce in the literature with most studies utilizing rodents. While rodent studies provide valuable insights into basic mechanistic processes, the translation of novel therapeutic approaches to clinical practice often requires the use of large animal models. In exploring the intricate systems biology linking surgery and medici

SUBMITTER: Leishman DJ 

PROVIDER: S-EPMC11534753 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature