Acute-phase innate immune responses in SIVmac239-infected <i>Mamu-B*08+</i> Indian rhesus macaques may contribute to the establishment of elite control.

ABSTRACT:

Introduction

Spontaneous control of chronic-phase HIV/SIV viremia is often associated with the expression of specific MHC class I allotypes. HIV/SIV-specific CD8+ cytotoxic T lymphocytes (CTLs) restricted by these MHC class I allotypes appear to be critical for viremic control. Establishment of the elite controller (EC) phenotype is predictable in SIVmac239-infected Indian rhesus macaques (RMs), with approximately 50% of Mamu-B*08+ RMs and 20% of Mamu-B*17+ RMs becoming ECs. Despite extensive characterization of EC-associated CTLs in HIV/SIV-infected individuals, the precise mechanistic basis of elite control remains unknown. Because EC and non-EC viral load trajectories begin diverging by day 14 post-infection, we hypothesized that hyperacute innate immune responses

SUBMITTER: Rosen BC 

PROVIDER: S-EPMC11534762 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature