Comparative associations of non-alcoholic fatty liver disease and metabolic dysfunction-associated steatotic liver disease with risk of incident chronic kidney disease: a cohort study.

ABSTRACT:

Background

We examined the comparative associations between non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) definitions with risk of developing chronic kidney disease (CKD) and abnormal albuminuria.

Methods

We conducted a cohort study of 214,145 Korean adults with normal kidney function at baseline who underwent liver ultrasonography. Participants were further subdivided into no steatotic liver disease (no-SLD), NAFLD-only, MASLD-only, both NAFLD and MASLD, and SLD not categorized as NAFLD or MASLD groups. Cox proportional hazards models were used to analyze the risk of incident CKD and albuminuria.

Results

Compared with either the no-NAFLD or no-MASLD groups, the NAFLD and MASLD groups were associated wit

SUBMITTER: Heo JH 

PROVIDER: S-EPMC11534778 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature