Klebsiella pneumoniae with carbapenemases: high prevalence of sequence type 307 with bla_OXA181 in South African community hospitals.

ABSTRACT: This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug resistant (XDR) ST307 with bla_OXA-181 on IncX3 plasmids was endemic in Gauteng community hospitals leaving limited options for treating in- and outpatient urinary tract infections. High-level ceftazidime/avibactam resistance was detected among isolates harbouring bla_OXA-48-like including bla_OXA-181. These findings highlighted the need for genomic methodologies suitable for lower- and middle-income countries to track XDR clones and plasmids in community hospitals. Such results will aid with treatment and stewardship strategies.

SUBMITTER: Salvador-Oke KT 

PROVIDER: S-EPMC11534848 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature