The role of circulating cytokines in heart failure: a bidirectional, two-sample Mendelian randomization study.

ABSTRACT:

Background

Cytokines play a pivotal role in the progression of heart failure (HF) by modulating inflammatory responses, promoting vasoconstriction, and facilitating endothelial injury. However, it is now difficult to distinguish the causal relationship between HF and cytokines in observational studies. Mendelian randomization (MR) analyses of cytokines probably could enhance our comprehension to the underlying biological processes of HF.

Methods

This study was to explore the correlation between 41 cytokines with HF at the genetic level by MR analysis. We selected a HF dataset from the Heart Failure Molecular Epidemiology for Therapeutic Targets (HERMES) 2018 and a cytokine dataset from a meta-analysis of cytokine levels in Finns. Two-sample, bidirectional MR analyses were pe

SUBMITTER: Zheng H 

PROVIDER: S-EPMC11534875 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature