Reward recalibrates rule representations in human amygdala and hippocampus intracranial recordings.

ABSTRACT: Adaptive behavior requires the ability to shift responding within (intra-dimensional) or between (extra-dimensional) stimulus dimensions when reward contingencies change. Studies of shifting in humans have focused mainly on the prefrontal cortex and/ or have been restricted to indirect measures of neural activity such as fMRI and lesions. Here, we demonstrate the importance of the amygdala and hippocampus by recording local field potentials directly from these regions intracranially in human epilepsy patients. Reward signals were coded in the high frequency gamma activity (HFG; 60-250 Hz) of both regions and synchronised via low frequency (3-5 Hz) phase-locking only after a shift when patients did not already know the rule and it signalled to stop shifting ("Win-Stay"). In contrast, HFG pu

SUBMITTER: Manssuer L 

PROVIDER: S-EPMC11535001 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature