Cannabinoid regulation of sex-dependent murine odorant-stimulated salivation.

ABSTRACT: Salivation is easily taken for granted, but without normal salivation, simple essential tasks such as chewing and swallowing become difficult, with consequences for quality of life, nutrition and oral health. Many important drug classes cause dry mouth as a side effect, contributing substantially to patient non-compliance. Available treatments are mostly palliative. Cannabis user complaints of dry mouth prompted a study that showed that basal salivation is likely regulated by cannabinoid CB1 receptors on neurons that innervate the submandibular gland. But what about stimulated salivation? The adjoining parotid gland releases saliva in response to olfactory or other cues and contributes a large portion of the net salivation in humans. We investigated cannabinoid regulation of stimulated sal

SUBMITTER: Murataeva N 

PROVIDER: S-EPMC11535013 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature