Malignant Salivary Gland Neoplasm of the Tongue Base with EWSR1::BEND2 Fusion: An Unusual Case with Literature Review.

ABSTRACT:

Purpose

Salivary gland malignancies may have overlapping architectural patterns, tumor morphology, and immunohistochemical phenotypes, presenting challenges in precise classification. Molecular phenotyping has become quite useful for providing an additional diagnostic modality, and potential drug targets. Here we reported a young female patient with salivary gland tumor of the tongue base harboring genetic alterations by next generation sequencing (NGS).

Methods

The morphological, immunohistochemical and molecular features of this case were described, and related literature was reviewed.

Results

The tumor showed an epithelial myoepithelial architecture arranged in cords and tubules interwoven with a chondromyxoid stroma, along with perineural invasion and adjacent str

SUBMITTER: Zhang YD 

PROVIDER: S-EPMC11535138 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature