ERO1A levels are a prognostic indicator in EGFR mutated non small cell lung cancer.

ABSTRACT: We have identified endoplasmic reticulum oxidoreductase 1 alpha (ERO1A) as a poor prognostic indicator in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (EGFR^MUT-NSCLC). In addition, comparison of high versus low ERO1A expression among cohorts of EGFR^MUT-NSCLC primary samples revealed that ERO1A expression correlated with increased expression of proteins that regulate secretion. Using the CPTAC proteomic data set in lung adenocarcinoma we found that high ERO1A protein expression correlated with both extracellular matrix and matrix modifying enzymes. In this report, we found that ablating ERO1A expression was a determinant of clonogenicity, tumor sphere formation, spheroid growth and growth in vivo, as well as response to Osimertinib. We val

SUBMITTER: Voronkova MA 

PROVIDER: S-EPMC11535241 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature