Enhanced sperm isolation via bulk acoustic waves for high-throughput motility screening.

ABSTRACT: The increasing infertility rate has become a worrying global challenge in recent years. According to the report of the World Health Organization, the male factor is responsible for over half of infertility cases, which includes the lack of desirable characteristics in sperm motility, morphology, and DNA integrity. In recent years, it has been shown that clinical methods including density gradient centrifugation cause damage to sperm DNA and besides being invasive, they are costly and time-consuming. In contrast, microfluidics has been used as a promising and non-invasive approach to manipulate biological cells. Here, by using the microvortices created by the oscillation of the bubbles caused by the bulk acoustic waves, we were able to trap sperms with less motility. In contrast, the highly

SUBMITTER: Saeidpour Z 

PROVIDER: S-EPMC11535287 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature