Decoupled transcript and protein concentrations ensure histone homeostasis in different nutrients.

ABSTRACT: To maintain protein homeostasis in changing nutrient environments, cells must precisely control the amount of their proteins, despite the accompanying changes in cell growth and biosynthetic capacity. As nutrients are major regulators of cell cycle length and progression, a particular challenge arises for the nutrient-dependent regulation of 'cell cycle genes', which are periodically expressed during the cell cycle. One important example are histones, which are needed at a constant histone-to-DNA stoichiometry. Here we show that budding yeast achieves histone homeostasis in different nutrients through a decoupling of transcript and protein abundance. We find that cells downregulate histone transcripts in poor nutrients to avoid toxic histone overexpression, but produce constant amounts of

SUBMITTER: Chatzitheodoridou D 

PROVIDER: S-EPMC11535423 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature