The characterization of an IncN-IncR fusion plasmid co-harboring bla_TEM-40, bla_KPC-2, and bla_IMP-4 derived from ST1393 Klebsiella pneumoniae.

ABSTRACT: Plasmids, as important genetic elements apart from chromosomes, often carry multiple resistance genes and various mobile genetic elements, enabling them to acquire more exogenous genes and confer additional resistance phenotypes to bacteria. Various carbapenem resistance genes are often located on IncN plasmids, and several reports have linked fusion plasmids to IncN plasmids. Therefore, this study aims to explore the emergence, molecular structure characteristics, and resistance features mediated by IncN fusion plasmids carrying multiple carbapenem resistance genes. In this study, species identification was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS). Polymerase chain reaction (PCR) was employed to detect the presence of carb

SUBMITTER: Fang L 

PROVIDER: S-EPMC11535437 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature