Plasma phosphorylated-tau217 is increased in Niemann-Pick disease type C.

ABSTRACT: Niemann-Pick disease type C and Alzheimer's disease are distinct neurodegenerative disorders that share the presence of neurofibrillary tangle pathology. In this multicentre study, we measured plasma phosphorylated-tau217 in controls (n = 60), Niemann-Pick disease type C (n = 71) and Alzheimer's disease (n = 30 positive for amyloid and negative for tau in CSF [A⁺T^-] and n = 30 positive for both [A⁺T⁺]). Annual Severity Increment Score and Lysotracker measurements were evaluated in the Niemann-Pick disease type C group to estimate the rate of progression and lysosomal enlargement, respectively. In the cross-sectional analysis, plasma phosphorylated-tau217 was increased in Niemann-Pick disease type C compared with contro

SUBMITTER: Gonzalez-Ortiz F 

PROVIDER: S-EPMC11535543 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature