Multiscale, mechanistic model of Rheumatoid Arthritis to enable decision making in late stage drug development.

ABSTRACT: Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disease that affects about 0.1% to 2% of the population worldwide. Despite the development of several novel therapies, there is only limited benefit for many patients. Thus, there is room for new approaches to improve response to therapy, including designing better trials e.g., by identifying subpopulations that can benefit from specific classes of therapy and enabling reverse translation by analyzing completed clinical trials. We have developed an open-source, mechanistic multi-scale model of RA, which captures the interactions of key immune cells and mediators in an inflamed joint. The model consists of a treatment-naive Virtual Population (Vpop) that responds appropriately (i.e. as reported in clinical trials) to standard-of

SUBMITTER: Bedathuru D 

PROVIDER: S-EPMC11535547 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature