Solitude and serotonin: juvenile isolation alters the covariation between social behavior and cFos expression by serotonergic neurons.

ABSTRACT: Variation in the mutual responsiveness of social partners to each other can be reflected in behavioral suites that covary with neural activity in ways that track the salience or valence of interactions. Juvenile social isolation alters social behavior and neural activity during social interaction, but whether and how it alters the covariation between behavior and neural activity has not been as well explored. To address this issue, four classes of experimental subjects: isolated males, socially housed males, isolated females, and socially housed females, were paired with an opposite-sex social partner that had been socially housed. Social behaviors and c-Fos expression in the serotonergic dorsal raphe nucleus (DRN) were then measured in subjects following the social interactions. Relative

SUBMITTER: Hutchens SED 

PROVIDER: S-EPMC11535725 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature