Quantitative proteomics reveal the protective effects of Qiang Jing decoction against oligoasthenospermia via modulating spermatogenesis related-proteins.

ABSTRACT:

Background

According to the current situation, the treatment of oligoasthenospermia with Western medicine is still full of challenges. Qiang Jing decoction (QJD) is used for treating male infertility as a traditional Chinese medicine (TCM) prescription. In this study. we will try to uncover the molecular mechanism of QJDs in treating oligoasthenospermia based on the proteomics technology.

Methods

In this study, sperm quality from oligoasthenospermia model, QJD treatment, and control rats were analyzed. Tandem mass tag (TMT) quantitative proteomics was used for the comparative analysis of protein abundance in rat testis of different treatment.

Results

The therapeutic effect of QJDs on spermatogenesis function by improving sperm quality was confirmed in the present expe

SUBMITTER: Wang D 

PROVIDER: S-EPMC11535736 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature