Insights into sex differences in perioperative outcomes of non-small cell lung cancer patients.

ABSTRACT:

Background

The appreciation of sex differences is substantial for precise cancer management. Surgery is the main treatment for non-small cell lung cancer (NSCLC). We aimed to identify sex differences on perioperative outcomes in NSCLC patients and to uncover the origins of sex effect in outcomes using a Chinese cohort.

Methods

We retrospectively enrolled patients undergoing NSCLC surgery in the Western China Lung Cancer Database from January 2014 to April 2021. We compared baseline characteristics and perioperative outcomes between male and female. Multivariable analyses were performed. We conducted causal mediation analysis to identify drivers to sex differences in perioperative outcomes.

Results

Altogether, data of 10,181 patients (5,738 women and 4,443 men) were an

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC11535826 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature