Association between type III collagen degradation and local tissue damage of a single joint.

ABSTRACT:

Objective

The development of disease-modifying drugs is limited by OA's heterogeneity and the challenge of defining clinical endpoints. Serological biomarkers are considered potential surrogate endpoints, but their contribution from single joints to systemic levels in OA patients is unclear. In this exploratory study we longitudinally assessed systemic biomarker levels' response to tissue damage and healing before and after surgery in patients undergoing knee or hip joint replacement revision for aseptic failure. Patients with chronic pain associated with a prior hip or knee arthroplasty, but not receiving revision surgery were included as control.

Method

The serological biomarker of MMP mediated type III collagen degradation C3M, associated with synovial tissue degradation,

SUBMITTER: Thudium CS 

PROVIDER: S-EPMC11535998 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature