Relationship between MRI brain-age heterogeneity, cognition, genetics and Alzheimer's disease neuropathology.

ABSTRACT:

Background

Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals, with more pronounced ageing (older brain age) during midlife being indicative of later development of dementia. Here, we examined whether brain-ageing heterogeneity in unimpaired older adults related to neurodegeneration, different cognitive trajectories, genetic and amyloid-beta (Aβ) profiles, and to predicted progression to Alzheimer's disease (AD).

Methods

Functional and structural brain age measures were obtained for resting-state functional MRI and structural MRI, respectively, in 3460 cognitively normal individuals across an age range spanning 42-85 y

SUBMITTER: Antoniades M 

PROVIDER: S-EPMC11536027 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature