Local adaptive immunity in atherosclerosis with T cell activation by aortic dendritic cells accelerates pathogenesis.

ABSTRACT: Atherosclerosis represents a chronic inflammatory condition in arterial walls, where local immune cells significantly contribute to disease progression. This study employed various in situ immunological techniques to investigate the specific roles of aortic dendritic cell (DC) subsets in atherosclerotic animal models, distinguishing between normal and diseased immune contexts. Our findings revealed that aortic DCs, particularly the cDC1 subset, played a critical role in facilitating CD8⁺ T cell activation through antigen presentation. Additionally, atherosclerosis-induced increases in GM-CSF levels enhanced CCR7 expression on aortic monocyte-derived DCs, promoting their recruitment and IL-12 production for Th1 differentiation. Notably, immunizing pre-atherosclerotic mice

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11536043 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature