Association between asthma and IgG levels specific for rhinovirus and respiratory syncytial virus antigens in children and adults.

ABSTRACT:

Background

Viral infections in childhood, especially to rhinovirus (RV) and respiratory syncytial virus (RSV), are associated with asthma inception and exacerbation. However, little is known about the role of RV- and RSV-specific antibodies in childhood versus adult asthma.

Objective

We sought to investigate associations between RV- and RSV-specific IgG levels and asthma phenotypes in children and adults.

Methods

The analysis included 1771 samples from participants of the Epidemiological Study on the Genetics and Environment of Asthma (530 children; age [mean ± SD], 11.1 ± 2.8, and 1241 adults; age [mean ± SD], 43.4 ± 16.7, among whom 274 and 498 had ever asthma, respectively). RSV- and RV-specific IgG levels were determined using microarrayed virus-derived antigens a

SUBMITTER: Mauclin M 

PROVIDER: S-EPMC11536052 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature