A bio-feedback-mimicking electrode combining real-time monitoring and drug delivery.

ABSTRACT: Effective disease management based on real-time physiological changes presents a significant clinical challenge. A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized interventions. In this study, we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time monitoring. To prevent drug leakage, the system incorporates a magnesium (Mg) valve in the outer layer, ensuring zero leakage when drug release is not required. The middle layer contains a drug-laden poly(3,4-ethylenedioxythiophene) (PEDOT) sponge (P-sponge), which supplies the water to partially or fully activate the Mg valve under electrical stimulation and initiate drug release. Once the valve is fu

SUBMITTER: Liu S 

PROVIDER: S-EPMC11536068 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature