Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory.

ABSTRACT: The hippocampus is functionally specialized along its longitudinal axis with intricate interactions with cortical systems, which is crucial for understanding development and cognition. Using a well-established connectopic mapping technique on two large resting-state functional MRI datasets, we systematically quantified topographic organization of the hippocampal functional connectivity (hippocampal gradient) and its cortical interaction in developing brains. We revealed hippocampal functional hierarchy within the large-scale cortical brain systems, with the anterior hippocampus preferentially connected to an anterior temporal (AT) pathway and the posterior hippocampus embedded in a posterior medial (PM) pathway. We examined the developmental effects of the primary gradient and its whole-br

SUBMITTER: Xie H 

PROVIDER: S-EPMC11536083 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature