Deprescribing antipsychotics in patients with schizophrenia: findings from a specialized clinic.

ABSTRACT:

Background

While antipsychotic medication reduces the risk of relapse for patients with schizophrenia, high prevalence of adverse effects results in low adherence. Lower doses of antipsychotics have been associated with increased level of function but also with increased risk of relapse. This study presents findings from a specialized deprescribing clinic. In addition, we aim to identify clinical predictors for relapse.

Methods

Patients diagnosed with schizophrenia were referred to the clinic, which offers a six-month guided tapering program. Antipsychotic dose was reduced by 10% every four weeks. Patients were monitored closely for symptom progression or decrease in level of function, with defined cut-offs prompting a pause in or cessation of dose reduction.

Results

SUBMITTER: Nostdal A 

PROVIDER: S-EPMC11536106 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature