Impulsivity in first-degree relatives at risk of psychosis and mania: a systematic review and meta-analysis.

ABSTRACT: Impulsivity is elevated in psychosis and during mania in bipolar disorder. Studies in unaffected relatives may help establish whether impulsivity is a heritable, state independent endophenotype. The aim of this systematic review and meta-analysis was to examine whether impulsivity is elevated in unaffected relatives of those with bipolar disorder, schizophrenia, and schizoaffective disorder, compared to controls. Databases were systematically searched up until March 2023 for articles reporting data on a behavioral or self-report measure of impulsivity in first-degree relatives and controls. Nineteen studies were included. Behavioral (10 studies, d = 0.35, p < 0.001) and self-reported impulsivity was significantly elevated in bipolar disorder relatives compared to controls (5

SUBMITTER: Kerr-Gaffney J 

PROVIDER: S-EPMC11536112 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature