Patterns of abnormal activations in severe mental disorders a transdiagnostic data-driven meta-analysis of task-based fMRI studies.

ABSTRACT:

Background

Studies suggest severe mental disorders (SMDs), such as schizophrenia, major depressive disorder and bipolar disorder, are associated with common alterations in brain activity, albeit with a graded level of impairment. However, discrepancies between study findings likely to results from both small sample sizes and the use of different functional magnetic resonance imaging (fMRI) tasks. To address these issues, data-driven meta-analytic approach designed to identify homogeneous brain co-activity patterns across tasks was conducted to better characterize the common and distinct alterations between these disorders.

Methods

A hierarchical clustering analysis was conducted to identify groups of studies reporting similar neuroimaging results, independent of task type an

SUBMITTER: Boisvert M 

PROVIDER: S-EPMC11536122 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature