LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up.

ABSTRACT:

Background

Anxiety disorders are a major public health burden with limited treatment options.

Aims

We investigated the long-term safety and efficacy of lysergic acid diethylamide (LSD)-assisted therapy in patients with anxiety with or without life-threatening illness.

Method

This study was an a priori-planned long-term follow-up of an investigator-initiated, two-centre trial that used a double-blind, placebo-controlled, two-period, random-order, crossover design with two sessions with either oral LSD (200 μg) or placebo per period. Participants (n = 39) were followed up 1 year after the end-of-study visit to assess symptoms of anxiety, depression and long-term effects of psychedelics using Spielberger's State-Trait Anxiety Inventory-Global (STAI-G), the

SUBMITTER: Holze F 

PROVIDER: S-EPMC11536188 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature