Impact of early risk factors on schizophrenia risk and age of diagnosis: A Danish population-based register study.

ABSTRACT:

Background

While several risk factors for schizophrenia have been identified, their individual impacts are rather small. The relative independent and cumulative impacts of multiple risk factors on disease risk and age of onset warrant further investigation.

Study design

We conducted a register-based case-control study including all individuals receiving a schizophrenia spectrum disorder in Denmark from 1973 to 2018 (N = 29,142), and a healthy control sample matched 5:1 on age, sex, and parental socioeconomic status (N = 136,387). Register data included parental history of psychiatric illness, birth weight, gestational age, season of birth, population density of birthplace, immigration, paternal age, and Apgar scores. Data were analysed using logistic regression

SUBMITTER: Lemvigh CK 

PROVIDER: S-EPMC11536204 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature