Associations between C-reactive protein and individual symptoms of depression in a lower-middle income country.

ABSTRACT:

Background

Data on associations between inflammation and depressive symptoms largely originate from high income population settings, despite the greatest disease burden in major depressive disorder being attributed to populations in lower-middle income countries (LMICs).

Aims

We assessed the prevalence of low-grade inflammation in adults with treatment-resistant depression (TRD) in Pakistan, an LMIC, and investigated associations between peripheral C-reactive protein (CRP) levels and depressive symptoms.

Method

This is a secondary analysis of two randomised controlled trials investigating adjunctive immunomodulatory agents (minocycline and simvastatin) for Pakistani adults with TRD (n = 191). Logistic regression models were built to assess the relationship betw

SUBMITTER: Fellows E 

PROVIDER: S-EPMC11536211 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature