The plasma free fraction of 25-hydroxyvitamin D₃ is not strongly associated with 25-hydroxyvitamin D₃ clearance in kidney disease patients and controls.

ABSTRACT: Circulating 25-hydroxyvitamin D [25(OH)D] concentration is used to monitor vitamin D status. Plasma protein binding may influence the 25(OH)D dose-response to vitamin D treatment through a direct relationship between the plasma unbound ("free") fraction and clearance of 25(OH)D. We previously evaluated 25(OH)D₃ clearance in relation to kidney function using intravenous administration of deuterium labeled 25(OH)D₃. In this follow up study, we determined the free fraction of 25(OH)D₃ in plasma (i.e., percent free 25(OH)D₃) and the serum concentration and haplotype of vitamin D binding protein in these participants. We hypothesized that the percent free 25(OH)D₃ would be positively associated with 25(OH)D₃ clearance and would m

SUBMITTER: Best CM 

PROVIDER: S-EPMC11536320 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature